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Comprehensive profiling of small RNAs and their changes and linkages to mRNAs in schizophrenia and bipolar disorder

2024-12-25

Abstract excerpt

We investigated small non-coding RNAs (sncRNAs) from the prefrontal cortex of 93 individuals diagnosed with schizophrenia (SCZ) or bipolar disorder (BD) and 77 controls. We uncovered recurring complex sncRNA profiles, with 98% of all sncRNAs being accounted for by miRNA isoforms (60.6%), tRNA-derived fragments (17.8%), rRNA-derived fragments (11.4%), and Y RNA-derived fragments (8.3%). In SCZ, 15% of all sncRNAs e...

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Identifiers and source

Literature Corpus work
1e096dde-23e0-53b5-9cbe-2b57d5ae2df8
DOI
10.1101/2024.12.24.630254
Open publication

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Comprehensive profiling of small RNAs and their changes and linkages to mRNAs in schizophrenia and bipolar disorderDOI 10.1101/2024.12.24.630254
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