Article

Non-histone human chromatin protein, PC4 is critical for genomic integrity and negatively regulates autophagy

2018-02-18

Abstract excerpt

Multifunctional human transcriptional positive co-activator 4 (PC4) is a bonafide non-histone component of the chromatin and plays a pivotal role in the process of chromatin compaction and functional genome organization. Knockdown of PC4 expression leads to a drastic open conformation of the chromatin and thereby altered nuclear architecture, defects in chromosome segregation and changed epigenetic landscape. Inte...

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Literature Corpus work: 6288a972-0dc2-54c3-88a0-c8eff7e8b3e2
DOI: 10.1101/266932

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