Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

PC4-mediated Ku complex PARylation facilitates NHEJ-dependent DNA damage repair

10 Jul 2023

Abstract excerpt

Radiotherapy is one of the mainstay treatments for hepatocellular carcinoma (HCC). However, a substantial number of patients with HCC develop radioresistance and eventually suffer from tumor progression or relapse, which is a major impediment to the use of radiotherapy. Therefore, elucidating the mechanisms underlying radioresistance and identifying novel therapeutic targets to improve patient prognosis are...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to DNA Repair Mechanisms
Share to PARP inhibition in cancer therapy
Share to Radiation Therapy and Dosimetry

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 37437887
DOI: 10.1016/j.jbc.2023.105032

Provenance

PubMed metadata and Literature Corpus relationships.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

PC4-mediated Ku complex PARylation facilitates NHEJ-dependent DNA damage repairPMID 37437887Read ↗

Non-histone human chromatin protein, PC4 is critical for genomic integrity and negatively regulates autophagySemantic proximity Read ↗

Recruitment of RNA polymerase II cofactor PC4 to DNA damage sites.Semantic proximity Read ↗

Human Transcriptional Coactivator PC4 Stimulates DNA End Joining and Activates DSB Repair ActivitySemantic proximity Read ↗

TKT-PARP1 axis induces radioresistance by promoting DNA double-strand break repair in hepatocellular carcinomaSemantic proximity Read ↗

PARP10 promotes cellular proliferation and tumorigenesis by alleviating replication stressSemantic proximity Read ↗

DNA Repair Factor Poly(ADP-Ribose) Polymerase 1 Is a Proviral Factor in Hepatitis B Virus Covalently Closed Circular DNA FormationSemantic proximity Read ↗

Human PC4 supports telomere stability and viability in cells utilizing the alternative lengthening of telomeres mechanismSemantic proximity Read ↗

The oncoprotein DEK affects the outcome of PARP1/2 inhibition during replication stressSemantic proximity Read ↗

HPF1/C4orf27 Is a PARP-1-Interacting Protein that Regulates PARP-1 ADP-Ribosylation ActivitySemantic proximity Read ↗

DNA-PK—A Candidate Driver of Hepatocarcinogenesis and Tissue Biomarker That Predicts Response to Treatment and SurvivalSemantic proximity Read ↗

Rational combination therapy for hepatocellular carcinoma with PARP1 and DNA-PK inhibitorsSemantic proximity Read ↗

PCAF-Mediated Histone Acetylation Promotes Replication Fork Degradation by MRE11 and EXO1 in BRCA-Deficient Cells.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.