Article

S1-5: Modulation of Cancer and Stem Cell Biomarkers by the Notch Inhibitor MK-0752 Added to Endocrine Therapy for Early Stage ER+ Breast Cancer.

2011-12-01

Abstract excerpt

Abstract Background: New strategies to enhance endocrine therapy (ET) efficacy and/or overcome resistance by targeting key survival pathways are needed. Preclinical data indicate that unwanted effects of ET include reactivation of the Notch pathway, critical for breast tumor initiating (stem) cells. Notch inhibition with gamma secretase inhibitors (GSI) enhances tamoxifen (tam) efficacy in xenografts, but impact o...

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Identifiers and source

Literature Corpus work: 6279ad9a-230e-5a58-aedf-cb398c6c8636
DOI: 10.1158/0008-5472.sabcs11-s1-5

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