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Article

HER-2, Notch, and Breast Cancer Stem Cells: Targeting an Axis of Evil

10 Mar 2009

Abstract excerpt

Increasing evidence indicates that tumor-initiating (cancer stem) cells may contribute to treatment resistance and relapse, suggesting that improved clinical outcome will require effective targeting of this cell population. Recent studies suggest that the remarkable clinical efficacy of trastuzumab may relate to its ability to target cancer stem cell populations.

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Identifiers

PMID: 19276254
DOI: 10.1158/1078-0432.ccr-08-3087

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