Article

The efficacy of CB-103, a first-in-class transcriptional Notch inhibitor, in preclinical models of breast cancer

2023-07-07

Abstract excerpt

<h4>Background</h4> Notch signaling has been shown to mediate treatment resistance and support cancer stem cells (CSCs) in endocrine-resistant estrogen receptor positive (ER+) and triple negative breast cancers (TNBCs). The clinical development of GSIs, first generation Notch inhibitors, has been hindered by lack of Notch specificity and dose-limiting toxicity. Here we describe the safety and efficacy of a first-...

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Literature Corpus work: 37684421-de84-547c-ae29-6359217484f9
DOI: 10.1101/2023.07.06.547830

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