Back to search

Article

A liver-heart endocrine axis revealed by systems genetics and mediated by hepatocyte growth factor activator

2026-05-06

Abstract excerpt

The liver and heart are tightly interconnected organs, and liver disease is frequently accompanied by cardiovascular dysfunction, including heart failure 1–5 . Despite this clinical association, the mechanisms by which liver-derived endocrine signals influence cardiac gene programs and disease susceptibility remain poorly defined. Inter-organ endocrine communication is increasingly recognized as a key regulator o...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
625d4bf3-92d5-5a99-acc4-14d9f0c7547b
DOI
10.64898/2026.05.05.26352474
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
A liver-heart endocrine axis revealed by systems genetics and mediated by hepatocyte growth factor activatorDOI 10.64898/2026.05.05.26352474
Sex-biased long non-coding RNAs negatively correlated with sex-opposite protein coding gene co-expression networks in Diversity Outbred mouse liverSemantic proximity
Genetic factors contributing to extensive variability of sex-specific hepatic gene expression in Diversity Outbred miceSemantic proximity
A personalized, multi-omics approach identifies genes involved in cardiac hypertrophy and heart failureSemantic proximity
Modifications of the GH Axis Reveal Unique Sexually Dimorphic Liver Signatures for Lcn13, Asns, Hamp2, Hao2, and Pgc1aSemantic proximity
Longitudinal Multi-Organ Transcriptomic Atlas of Salt-Induced HypertensionSemantic proximity
The Effects of Sex and Diet on Physiology and Liver Gene Expression in Diversity Outbred MiceSemantic proximity
Genetic factors contributing to extensive variability of sex-specific hepatic gene expression in Diversity Outbred mice.Semantic proximity
Systems genetics of metabolic health in the BXD mouse genetic reference population.Semantic proximity
Brain-heart-eye axis revealed by multi-organ imaging, genetics and proteomicsSemantic proximity
Leveraging inter-individual transcriptional correlation structure to infer discrete signaling mechanisms across metabolic tissuesSemantic proximity
Genetic Determinants of Heart Failure Susceptibility and Response in the Collaborative Cross Mouse PopulationSemantic proximity
Feminization of Male Mouse Liver by Persistent Growth Hormone Stimulation: Activation of Sex-Biased Transcriptional Networks and Dynamic Changes in Chromatin StatesSemantic proximity
Select a neighboring publication to make it the new centre.