Article
Functional validity, role, and implications of heavy alcohol consumption genetic loci.
Science advances - 1 Jan 2020
Thompson Andrew, Cook James, Choquet Hélène, Jorgenson Eric, Yin Jie, Kinnunen Tarja, Barclay Jeff, Morris Andrew P, Pirmohamed Munir
Abstract excerpt
High alcohol consumption is a risk factor for morbidity and mortality, yet few genetic loci have been robustly associated with alcohol intake. Here, we use U.K. Biobank (n = 125,249) and GERA (n = 47,967) datasets to determine genetic factors associated with extreme population-level alcohol consumption and examine the functional validity of outcomes using model organisms and in silico techniques. We identified...
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