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Article

Natural variation suggests candidate genes underlying Caenorhabditis elegans susceptibility to diverse toxicants.

Toxicological sciences : an official journal of the Society of Toxicology - 2 Mar 2026

Crombie Timothy A, Mckeown Ryan, Widmayer Samuel J, Shaver Amanda O, Moya Nicolas D, Collins J B, Wit Janneke, Tanny Robyn E, Braendle Christian, Stevens Lewis, Van Sluijs Lisa, Rockman Matthew V, Sterken Mark G, Félix Marie-Anne, Andersen Erik C

Abstract excerpt

Genetic differences among individuals shape how they respond to environmental toxicants, but the identification and validation of the genes responsible for this variation is difficult, particularly in humans. Consequently, our limited knowledge of the genes that influence susceptibility constrains our ability to accurately predict the risks posed by environmental toxicants. To identify genes underlying natural...

Topics

Animals
Caenorhabditis elegans
Genome-Wide Association Study
Genetic Variation
Environmental Pollutants
Larva

Source

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 41706139
DOI: 10.1093/toxsci/kfag019
PMCID: PMC13462801

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

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