Article

Tumor Evolution Decoder (TED): Unveiling Tumor Evolution Based on Mutation Profiles of Subclones or Single Cells

2019-05-09

Abstract excerpt

Cancer cells constantly evolve accumulating somatic mutations. To describe the tumor evolution process, we develop the Tumor Evolution Decoder (TED), a novel algorithm for constructing phylogenetic tree based on somatic mutation profiles of tumor subclones or single cells. TED takes a unique strategy that reduces the total number of duplicated mutations and dropout mutations in the tumor evolution process, which h...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 62286fa2-a303-5560-bcdd-a8e3dffaf6c3
DOI: 10.1101/633610

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Tumor Evolution Decoder (TED): Unveiling Tumor Evolution Based on Mutation Profiles of Subclones or Single CellsDOI 10.1101/633610Read

Joint inference of exclusivity patterns and recurrent trajectories from tumor mutation treesSemantic proximity Read

Model-based tumor subclonal reconstructionSemantic proximity Read

Joint inference of exclusivity patterns and recurrent trajectories from tumor mutation trees.Semantic proximity Read

OncoNEM: inferring tumor evolution from single-cell sequencing data.Semantic proximity Read

Cancer evolution: mathematical models and computational inference.Semantic proximity Read

Phylomedicine of mutational processes in somatic cancer cell populationsSemantic proximity Read

Using single cell sequencing data to model the evolutionary history of a tumor.Semantic proximity Read

The Evolutionary Landscape of Pan-Cancer Drives Clinical AggressionSemantic proximity Read

Pharming: Joint Clonal Tree Reconstruction of SNV and CNA Evolution from Single-cell DNA Sequencing of TumorsSemantic proximity Read

A Phylogenetic Approach to Inferring the Order in Which Mutations Arise during Cancer ProgressionSemantic proximity Read

SCARLET: Single-cell tumor phylogeny inference with copy-number constrained mutation losses.Semantic proximity Read

Computational enhancement of single-cell sequences for inferring tumor evolutionSemantic proximity Read