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Lower Hippocampal Volume Partly Mediates the Association Between rs6859 in the <i>NECTIN2</i> Gene and Alzheimer’s Disease: New Findings from Causal Mediation Analysis of ADNI Data

2025-09-04

Abstract excerpt

Infections may contribute to neurodegeneration, including Alzheimer’s disease (AD). Polymorphism in the NECTIN2 gene has been linked to both AD and vulnerability to infections. We hypothesized that neurodegeneration may mediate the connection between this polymorphism and AD. To test this hypothesis, we conducted a causal mediation analysis (CMA) using the Alzheimer’s Disease Neuroimaging Initiative (ADNI) data. W...

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Literature Corpus work
6227e267-7c76-5aa8-b0eb-21b671e08047
DOI
10.1101/2025.09.02.25334930
Open publication

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Lower Hippocampal Volume Partly Mediates the Association Between rs6859 in the <i>NECTIN2</i> Gene and Alzheimer’s Disease: New Findings from Causal Mediation Analysis of ADNI DataDOI 10.1101/2025.09.02.25334930
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