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The association between rs6859 in NECTIN2 gene and Alzheimer’s disease is partly mediated by pTau

6 Aug 2024

Abstract excerpt

Introduction Emerging evidence suggests a connection between vulnerability to infections and Alzheimer’s disease (AD). The nectin cell adhesion molecule 2 (NECTIN2) gene coding for a membrane component of adherens junctions is involved in response to infections, and its single nucleotide polymorphism (SNP) rs6859 was significantly associated with AD risk in several human cohorts. It is unclear, however, how...

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PMID: 39165837
DOI: 10.3389/fnagi.2024.1388363

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