Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Two Ligand-Binding Sites on SARS-CoV-2 Non-Structural Protein 1 Revealed by Fragment-Based X-ray Screening

18 Oct 2022

Abstract excerpt

The regular reappearance of coronavirus (CoV) outbreaks over the past 20 years has caused significant health consequences and financial burdens worldwide. The most recent and still ongoing novel CoV pandemic, caused by Severe Acute Respiratory Syndrome coronavirus 2 (SARS-CoV-2) has brought a range of devastating consequences. Due to the exceptionally fast development of vaccines, the mortality rate of the virus...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to interferon and immune responses
Share to SARS-CoV-2 and COVID-19 Research
Share to Viral gastroenteritis research and epidemiology

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 36293303
DOI: 10.3390/ijms232012448

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Two Ligand-Binding Sites on SARS-CoV-2 Non-Structural Protein 1 Revealed by Fragment-Based X-ray ScreeningPMID 36293303Read ↗

Revealing druggable cryptic pockets in the Nsp1 of SARS-CoV-2 and other β-coronaviruses by simulations and crystallographySemantic proximity Read ↗

Revealing druggable cryptic pockets in the Nsp-1 of SARS-CoV-2 and other β-coronaviruses by simulations and crystallographySemantic proximity Read ↗

Structure of nonstructural protein 1 from SARS-CoV-2Semantic proximity Read ↗

Structural characterization of Nonstructural protein 1 from SARS-CoV-2Semantic proximity Read ↗

Structural characterization of nonstructural protein 1 from SARS-CoV-2Semantic proximity Read ↗

Identification of residues of SARS-CoV nsp1 that differentially affect inhibition of gene expression and antiviral signaling.Semantic proximity Read ↗

Targeting SARS-CoV-2 Non-Structural ProteinsSemantic proximity Read ↗

Structure of the SARS-CoV-2 Nsp1/5′-Untranslated Region Complex and Implications for Potential Therapeutic Targets, a Vaccine, and VirulenceSemantic proximity Read ↗

An immunoinformatics approach to study the epitopes contributed by Nsp13 of SARS-CoV-2Semantic proximity Read ↗

Structural basis for translational shutdown and immune evasion by the Nsp1 protein of SARS-CoV-2Semantic proximity Read ↗

Analysis of critical protein-protein interactions of SARS-CoV-2 capping and proofreading molecular machineries towards designing dual target inhibitory peptidesSemantic proximity Read ↗

Fragment Binding to the Nsp3 Macrodomain of SARS-CoV-2 Identified Through Crystallographic Screening and Computational DockingSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.