Article

Integrated Stress Response Mediates Early Endothelial Adaptation to Serum Deprivation

2025-12-18

Abstract excerpt

Endothelial cells are continuously exposed to fluctuations in circulating blood composi-tion and must rapidly adapt to changes in nutrient and growth factor availability. Here, we investigated how serum deprivation—a model of trophic stress—affects stress adapta-tion pathways in human umbilical vein endothelial cells (HUVECSs), focusing on the in-tegrated stress response (ISR), a key mechanism in cellular adaptati...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 621b0728-effa-5e10-92c1-868c8f502c37
DOI: 10.20944/preprints202512.1506.v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Integrated Stress Response Mediates Early Endothelial Adaptation to Serum DeprivationDOI 10.20944/preprints202512.1506.v1Read

Mechanical forces and metabolic changes cooperate to drive cellular memory and endothelial phenotypes.Semantic proximity Read

Hyperglycemic conditions induce rapid cell dysfunction-promoting transcriptional alterations in human aortic endothelial cellsSemantic proximity Read

Hypoxia-Induced Changes in Endothelial Cell Phenotype and Function.Semantic proximity Read

Biomechanical activation of vascular endothelium as a determinant of its functional phenotype.Semantic proximity Read

Endothelial heterogeneity shapes shear stress response: a transcriptomic perspectiveSemantic proximity Read

Gene expression profile of human endothelial cells exposed to sustained fluid shear stress.Semantic proximity Read

The endothelial response to oxygen deprivation: biology and clinical implicationsSemantic proximity Read

Short- and Long-Term Endothelial Inflammation Have Distinct Effects and Overlap with Signatures of Cellular SenescenceSemantic proximity Read

Short- and Long-Term Endothelial Inflammation Have Distinct Effects and Overlap with Signatures of Cellular SenescenceSemantic proximity Read

Systems biology analysis of longitudinal functional response of endothelial cells to shear stressSemantic proximity Read

Adaptive response of vascular endothelial cells to an acute increase in shear stress magnitude.Semantic proximity Read

Longitudinal shear stress response in human endothelial cells to atheroprone and atheroprotective conditions.Semantic proximity Read