Article

Pharmacologic activation of Δ133p53α reduces cellular senescence in progeria patients-derived cells

2025-07-31

Abstract excerpt

<h4>Background</h4> Patients with Hutchinson-Gilford progeria syndrome (HGPS) show accelerated aging phenotypes and have shortened lifespan, with implications in physiological aging processes as well. While therapeutic approaches targeting the disease-causing abnormal protein, progerin, have been developed, further efforts to explore mechanistically distinct and complementary strategies are still critical to bett...

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Literature Corpus work: 023a9472-3e52-5e8d-bc8d-c97796dfd282
DOI: 10.1101/2025.07.28.667224

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