Article
Differential stem cell aging kinetics in Hutchinson-Gilford progeria syndrome and Werner syndrome.
Protein & cell - 1 Apr 2018
Wu Zeming, Zhang Weiqi, Song Moshi, Wang Wei, Wei Gang, Li Wei, Lei Jinghui, Huang Yu, Sang Yanmei, Chan Piu, Chen Chang, Qu Jing, Suzuki Keiichiro, Belmonte Juan Carlos Izpisua, Liu Guang-Hui
Abstract excerpt
Hutchinson-Gilford progeria syndrome (HGPS) and Werner syndrome (WS) are two of the best characterized human progeroid syndromes. HGPS is caused by a point mutation in lamin A (LMNA) gene, resulting in the production of a truncated protein product-progerin. WS is caused by mutations in WRN gene, encoding a loss-of-function RecQ DNA helicase. Here, by gene editing we created isogenic human embryonic stem cells...
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