Article

A genome wide antigen-antibody screen identifies a yeast-based therapeutic vaccine candidate for Chagas disease

2026-06-13

Abstract excerpt

Chagas disease is caused by Trypanosoma cruzi infection and results in decades-long, chronic, debilitating, and lethal disease. There is no vaccine available, largely due to the lack of vaccine targets. We generated a T. cruzi genome-wide library for yeast surface display and screened it with antibodies from Chagas disease patients to identify antigen-antibody interactions. We identified hundreds of T. cruzi an...

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Literature Corpus work: 61f7a1e7-e0c5-55b8-baa7-811dbb036b4e
DOI: 10.64898/2026.06.12.731947

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