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Identification of highly conserved Trypanosoma cruzi antigens for the development of a universal serological diagnostic assay

21 Feb 2024

Abstract excerpt

Chagas Disease is an important neglected tropical disease caused by Trypanosoma cruzi.There is no gold standard for diagnosis and commercial serological tests perform poorly in certain locations.By aligning T. cruzi genomes covering parasite genetic and geographic diversity, we identified highly conserved proteins that could serve as universal antigens for improved diagnosis.Their antigenicity was tested in...

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PMID: 38381980
DOI: 10.1080/22221751.2024.2315964

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