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Recombination-driven generation of the largest pathogen repository of antigen variants in the protozoan Trypanosoma cruzi

13 Sept 2016

Abstract excerpt

BACKGROUND: The protozoan parasite Trypanosoma cruzi, causative agent of Chagas disease, depends upon a cell surface-expressed trans-sialidase (ts) to avoid activation of complement-mediated lysis and to enhance intracellular invasion. However these functions alone fail to account for the size of this gene family in T. cruzi, especially considering that most of these genes encode proteins lacking ts enzyme...

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PMID: 27619017
DOI: 10.1186/s12864-016-3037-z

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