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A refined genome phage display methodology delineates the human antibody response in patients with Chagas disease

15 May 2021

Abstract excerpt

Summary Large-scale mapping of antigens and epitopes is pivotal for developing immunotherapies but challenging, especially for eukaryotic pathogens, owing to their large genomes. Here, we developed an integrated platform for genome phage display (gPhage) to show that unbiased libraries of the eukaryotic parasite Trypanosoma cruzi enable the identification of thousands of antigens recognized by serum samples from...

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PMID: 34142048
DOI: 10.1016/j.isci.2021.102540

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