Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Gene-Edited Interleukin CAR-T Cells Therapy in the Treatment of Malignancies: Present and Future

27 Jul 2021

Abstract excerpt

In recent years, chimeric antigen receptor T cells (CAR-T cells) have been faced with the problems of weak proliferation and poor persistence in the treatment of some malignancies. Researchers have been trying to perfect the function of CAR-T by genetically modifying its structure. In addition to the participation of T cell receptor (TCR) and costimulatory signals, immune cytokines also exert a decisive role in...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to CAR-T cell therapy research
Share to Viral Infectious Diseases and Gene Expression in Insects
Share to Virus-based gene therapy research

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 34386015
DOI: 10.3389/fimmu.2021.718686

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Gene-Edited Interleukin CAR-T Cells Therapy in the Treatment of Malignancies: Present and FuturePMID 34386015Read ↗

CAR T-cell Therapy: A New Era in Cancer ImmunotherapySemantic proximity Read ↗

Genetic Modification of Cytokine Signaling to Enhance Efficacy of CAR T Cell Therapy in Solid Tumors.Semantic proximity Read ↗

Chimeric antigen receptor T (CAR-T) cells expanded with IL-7/IL-15 mediate superior antitumor effectsSemantic proximity Read ↗

CAR-T-Cell Therapy: Present Progress and Future strategiesSemantic proximity Read ↗

Current and future concepts for the generation and application of genetically engineered CAR-T and TCR-T cellsSemantic proximity Read ↗

Therapeutic Applications of Engineered Chimeric Antigen Receptors-T cell for Cancer TherapySemantic proximity Read ↗

Chimeric Antigen Receptors Modified T-Cells for Cancer TherapySemantic proximity Read ↗

Fifteen Years of Gene Therapy Based on Chimeric Antigen Receptors: “Are We Nearly There Yet?”Semantic proximity Read ↗

The Advance Cancer Immunotherapy Techniques and the Future Perspective of Modified T Cell TherapySemantic proximity Read ↗

Modulating the differentiation status of ex vivo-cultured anti-tumor T cells using cytokine cocktails.Semantic proximity Read ↗

Chimeric Antigen Receptor Based Cellular Therapy for Treatment Of T-Cell MalignanciesSemantic proximity Read ↗

Genetically engineered T cells for cancer immunotherapySemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.