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Establishment of FUT8 gene knockout CHO cell line with stable expression of monoclonal antibody

2023-12-07

Abstract excerpt

<h4>Background: </h4> Afucosylated antibodies have been become increasingly popular in clinical trials for therapeutic purposes owing to the improved efficacy compared to the fucosylated counterparts. The elimination of fucose on the heavy chain of an antibody can enhance the activity of antibody-dependent cellular cytotoxicity (ADCC). However, antibodies produced by Chinese hamster ovary (CHO) cells are heavily f...

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Literature Corpus work
61d779f5-b40c-5178-a5b2-37a97c2b9d02
DOI
10.21203/rs.3.rs-3691208/v1
Open publication

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Establishment of FUT8 gene knockout CHO cell line with stable expression of monoclonal antibodyDOI 10.21203/rs.3.rs-3691208/v1
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