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Tomatidine Is a Lead Antibiotic Molecule That Targets Staphylococcus aureus ATP Synthase Subunit C.

Antimicrobial agents and chemotherapy - 1 Jun 2018

Lamontagne Boulet Maxime, Isabelle Charles, Guay Isabelle, Brouillette Eric, Langlois Jean-Philippe, Jacques Pierre-Étienne, Rodrigue Sébastien, Brzezinski Ryszard, Beauregard Pascale B, Bouarab Kamal, Boyapelly Kumaraswamy, Boudreault Pierre-Luc, Marsault Éric, Malouin François

Abstract excerpt

Methicillin-resistant Staphylococcus aureus (MRSA) is a leading cause of deadly hospital-acquired infections. The discovery of anti-Staphylococcus antibiotics and new classes of drugs not susceptible to the mechanisms of resistance shared among bacteria is imperative. We recently showed that tomatidine (TO), a steroidal alkaloid from solanaceous plants, possesses potent antibacterial activity against S. aureus...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 29610201
DOI: 10.1128/AAC.02197-17
PMCID: PMC5971568

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