Article

Systematic dissection of biases in whole-exome and whole-genome sequencing reveals major determinants of coding sequence coverage

2018-08-09

Abstract excerpt

Next generation DNA sequencing technologies are rapidly transforming the world of human genomics. Advantages and diagnostic effectiveness of the two most widely used resequencing approaches, whole exome (WES) and whole genome (WGS) sequencing, are still frequently debated. In our study we developed a set of statistical tools to systematically assess coverage of CDS regions provided by several modern WES platforms,...

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Literature Corpus work: 61797862-40b3-5115-8422-a5bb6da36a2a
DOI: 10.1101/387639

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