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Article

Whole-genome sequencing is more powerful than whole-exome sequencing for detecting exome variants.

Proceedings of the National Academy of Sciences of the United States of America - 28 Apr 2015

Belkadi Aziz, Bolze Alexandre, Itan Yuval, Cobat Aurélie, Vincent Quentin B, Antipenko Alexander, Shang Lei, Boisson Bertrand, Casanova Jean-Laurent, Abel Laurent

Abstract excerpt

We compared whole-exome sequencing (WES) and whole-genome sequencing (WGS) in six unrelated individuals. In the regions targeted by WES capture (81.5% of the consensus coding genome), the mean numbers of single-nucleotide variants (SNVs) and small insertions/deletions (indels) detected per sample were 84,192 and 13,325, respectively, for WES, and 84,968 and 12,702, respectively, for WGS. For both SNVs and indels,...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 25827230
DOI: 10.1073/pnas.1418631112
PMCID: PMC4418901

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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