Article
Comprehensive characterization of human genome variation by high coverage whole-genome sequencing of forty four Caucasians.
PloS one - 1 Jan 2013
Shen Hui, Li Jian, Zhang Jigang, Xu Chao, Jiang Yan, Wu Zikai, Zhao Fuping, Liao Li, Chen Jun, Lin Yong, Tian Qing, Papasian Christopher J, Deng Hong-Wen
Abstract excerpt
Whole genome sequencing studies are essential to obtain a comprehensive understanding of the vast pattern of human genomic variations. Here we report the results of a high-coverage whole genome sequencing study for 44 unrelated healthy Caucasian adults, each sequenced to over 50-fold coverage (averaging 65.8×). We identified approximately 11 million single nucleotide polymorphisms (SNPs), 2.8 million short...
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