Article
Screening the human exome: a comparison of whole genome and whole transcriptome sequencing.
Genome biology - 1 Jan 2010
Cirulli Elizabeth T, Singh Abanish, Shianna Kevin V, Ge Dongliang, Smith Jason P, Maia Jessica M, Heinzen Erin L, Goedert James J, Goldstein David B
Abstract excerpt
BACKGROUND: There is considerable interest in the development of methods to efficiently identify all coding variants present in large sample sets of humans. There are three approaches possible: whole-genome sequencing, whole-exome sequencing using exon capture methods, and RNA-Seq. While whole-genome sequencing is the most complete, it remains sufficiently expensive that cost effective alternatives are important....
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