Article

The effects of luminal and trans-endothelial fluid flows on the extravasation and tissue invasion of tumor cells in a 3D <i>in vitro</i> microvascular platform

2020-09-24

Abstract excerpt

<h4>ABSTRACT</h4> Throughout the process of metastatic dissemination, tumor cells are continuously subjected to mechanical forces resulting from complex fluid flows due to changes in pressures in their local microenvironments. While these forces have been associated with invasive phenotypes in 3D matrices, their role in key steps of the metastatic cascade, namely extravasation and subsequent interstitial migratio...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: ce8f8335-780c-5b5e-9908-93eec9ca0e64
DOI: 10.1101/2020.09.23.309872

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

The effects of luminal and trans-endothelial fluid flows on the extravasation and tissue invasion of tumor cells in a 3D <i>in vitro</i> microvascular platformDOI 10.1101/2020.09.23.309872Read

Microfluidic vascular models of tumor cell extravasationSemantic proximity Read

Interstitial flows promote amoeboid over mesenchymal motility of breast cancer cells revealed by a three dimensional microfluidic model.Semantic proximity Read

YAP localization mediates mechanical adaptation of human cancer cells during extravasation <i>in vivo</i>Semantic proximity Read

Microvasculature-on-a-Chip: Bridging the interstitial blood-lymph interface via mechanobiological stimuliSemantic proximity Read

Interstitial flow promotes macrophage polarization toward an M2 phenotype.Semantic proximity Read

Advances in tumor-endothelial cells co-culture and interaction on microfluidicsSemantic proximity Read

Mechanism of a flow-gated angiogenesis switch: early signaling events at cell-matrix and cell-cell junctions.Semantic proximity Read

Interstitial flow regulates the angiogenic response and phenotype of endothelial cells in a 3D culture model.Semantic proximity Read

Fluid flow exposure promotes Epithelial-to-Mesenchymal Transition and adhesion of breast cancer cells to endothelial cellsSemantic proximity Read

Investigating the impact of the interstitial fluid flow and hypoxia interface on cancer biology using a spheroid-on-chip perfusion systemSemantic proximity Read

Computational models of cancer cell transport through the microcirculation.Semantic proximity Read

Microfluidic Modulation of Microvasculature in Microdissected TumorsSemantic proximity Read