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Article

Classifying hepatitis B therapies with insights from covalently closed circular DNA dynamics

16 Dec 2023

Abstract excerpt

The achievement of a functional cure for chronic hepatitis B (CHB) remains limited to a minority of patients treated with currently approved drugs. The primary objective in developing new anti-HBV drugs is to enhance the functional cure rates for CHB. A critical prerequisite for the functional cure of CHB is a substantial reduction, or even eradication of covalently closed circular DNA (cccDNA). Within this...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 38110037
DOI: 10.1016/j.virs.2023.12.005

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