Back to search

Article

IL-34 ameliorates MASLD by regulating the synthesis of gut microbiota-derived metabolites LPS and IMP

2026-02-24

Abstract excerpt

<title>Abstract</title> <p>Previous studies have established that metabolic dysfunction-associated steatotic liver disease (MASLD) disrupts the intestinal barrier, allowing harmful microbial metabolites such as lipopolysaccharide (LPS) to translocate to the liver via the gut-liver axis and accelerate disease progression. While the conventional view holds that IL-34 plays a pro-inflammatory role in various disease...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
bad2335b-870a-5dd1-a194-5d09f5151765
DOI
10.21203/rs.3.rs-8820945/v1
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 10 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
IL-34 ameliorates MASLD by regulating the synthesis of gut microbiota-derived metabolites LPS and IMPDOI 10.21203/rs.3.rs-8820945/v1
Aromatic Microbial Metabolite Hippuric Acid Potentiates Pro-Inflammatory Responses in Macrophages through TLR-MyD88 Signaling and Lipid RemodelingSemantic proximity
Intestinal epithelium-derived high density lipoprotein restrains liver injury via the portal veinSemantic proximity
Jian Gan powder ameliorates immunological liver injury in mice by modulating the gut microbiota and metabolic profilesSemantic proximity
Nuclear factor interleukin 3 and metabolic dysfunction-associated fatty liver disease developmentSemantic proximity
Palm oil-containing high-fat diet with LPS and CCl4 C57BL/6J mouse model induces the progression of NASH/liver fibrosis and remodels the gut microbiota and its functionSemantic proximity
Gut Microbiota Protects Against Liver Injury and Fibrosis via Activation of the CYP Eicosanoid PathwaySemantic proximity
A Host Enzyme Reduces Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD) by Inactivating Intestinal LipopolysaccharideSemantic proximity
Multistrain Probiotic mixture VSL#3 ameliorates inflammation of Gut-Liver axis in bacterial endotoxin Lipopolysaccharide exposed miceSemantic proximity
A microbial metabolite reduces alcohol-induced inflammation via dual modulation of NF-κB and Interferon pathwaySemantic proximity
Inhibition of IRAK4 by microbial trimethylamine blunts metabolic inflammation and ameliorates glycemic controlSemantic proximity
Select a neighboring publication to make it the new centre.