Article

Mutations in the IgG B cell receptor associated with class-switched B cell lymphomas

2024-04-13

Abstract excerpt

<h4>Summary</h4> Immunoglobulin class-switching from IgM to IgG enhances B cell receptor (BCR) signalling 1,2 and promotes germinal centre (GC) B cell responses to antigens 3,4 . In contrast, non-Hodgkin lymphomas derived from GC B cells typically avoid IgG BCR expression and retain the unswitched IgM BCR, suggesting that the IgG BCR may protect B cells from malignant transformation 5,6 . However, the mechanis...

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Literature Corpus work: 612106f6-cea0-57df-8ea8-2e1746ab4068
DOI: 10.1101/2024.04.12.585865

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