Article

B cell receptor silencing reveals the origin of high-grade B cell lymphomas with <i>MYC</i> and <i>BCL2</i> rearrangements

2024-07-17

Abstract excerpt

The B cell receptor (BCR) is essential for mature B cell lymphomas, serving as therapeutic target. Here, we show that high-grade B cell lymphomas with MYC and BCL2 rearrangements (HGBCL-DH- BCL2 ) predominantly exhibit immunoglobulin heavy (IGH) chain silencing, leading to BCR shutdown. HGBCL-DH- BCL2 with undetectable IGH (IGH UND ) differ from IGH-expressing counterparts for germinal center-zone gene progra...

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Literature Corpus work: cce126c5-00d9-53c3-98e1-d82f35ca7f77
DOI: 10.1101/2024.07.13.603066

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