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Article

Loss of signalling via Gα13 in germinal centre B-cell-derived lymphoma.

Nature - 11 Dec 2014

Muppidi Jagan R, Schmitz Roland, Green Jesse A, Xiao Wenming, Larsen Adrien B, Braun Sterling E, An Jinping, Xu Ying, Rosenwald Andreas, Ott German, Gascoyne Randy D, Rimsza Lisa M, Campo Elias, Jaffe Elaine S, Delabie Jan, Smeland Erlend B, Braziel Rita M, Tubbs Raymond R, Cook J R, Weisenburger Dennis D, Chan Wing C, Vaidehi Nagarajan, Staudt Louis M, Cyster Jason G

Abstract excerpt

Germinal centre B-cell-like diffuse large B-cell lymphoma (GCB-DLBCL) is a common malignancy, yet the signalling pathways that are deregulated and the factors leading to its systemic dissemination are poorly defined. Work in mice showed that sphingosine-1-phosphate receptor-2 (S1PR2), a Gα12 and Gα13 coupled receptor, promotes growth regulation and local confinement of germinal centre B cells. Recent deep...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to GTP-Binding Protein alpha Subunits, G12-G13

Share to Lymphoma, Large B-Cell, Diffuse

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Source

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Identifiers

PMID: 25274307
DOI: 10.1038/nature13765
PMCID: PMC4267955

Genes

ARHGEF1
GNA13

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

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