Article

E3 ligase recruitment by UBQLN2 protects substrates from proteasomal degradation

2024-07-04

Abstract excerpt

Ubiquilins are a family of proteins critical to cellular proteostasis that are also linked to several neurodegenerative diseases, with specific mutations in UBQLN2 causing dominant, X-linked ALS. Despite an initial characterization as proteasomal shuttle factors, Ubiquilins have paradoxically been reported to stabilize numerous substrates. The basis of this triage decision remains enigmatic. Many other fundamental...

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Literature Corpus work: 60f23dc2-4777-533f-81fc-005e7128ba7d
DOI: 10.1101/2024.07.04.602059

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