Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Novel CRISPR-Associated Gene-Editing Systems Discovered in Metagenomic Samples Enable Efficient and Specific Genome Engineering

23 May 2023

Abstract excerpt

Development of medicines using gene editing has been hampered by enzymological and immunological impediments. We described previously the discovery and characterization of improved, novel gene-editing systems from metagenomic data. In this study, we substantially advance this work with three such gene-editing systems, demonstrating their utility for cell therapy development. All three systems are capable of...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to CAR-T cell therapy research
Share to CRISPR and Genetic Engineering
Share to Virus-based gene therapy research

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Source

Identifiers

PMID: 37219969
DOI: 10.1089/crispr.2022.0089

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 20 Oct 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Novel CRISPR-Associated Gene-Editing Systems Discovered in Metagenomic Samples Enable Efficient and Specific Genome EngineeringPMID 37219969Read ↗

Leveraging CRISPR gene editing technology to optimize the efficacy, safety and accessibility of CAR T-cell therapySemantic proximity Read ↗

The CRISPR-Cas12a Platform for Accurate Genome Editing, Gene Disruption, and Efficient Transgene Integration in Human Immune CellsSemantic proximity Read ↗

Increasing Gene Editing Efficiency via CRISPR/Cas9- or Cas12a-Mediated Knock-In in Primary Human T CellsSemantic proximity Read ↗

Combining different CRISPR nucleases for simultaneous knock-in and base editing prevents translocations in multiplex-edited CAR T cellsSemantic proximity Read ↗

Optimized RNP transfection for highly efficient CRISPR/Cas9-mediated gene knockout in primary T cellsSemantic proximity Read ↗

Boosting CAR-T cell therapy with CRISPR technologySemantic proximity Read ↗

Epigenetic profiles guide improved CRISPR/Cas9-mediated gene knockout in human T cellsSemantic proximity Read ↗

Building Potent Chimeric Antigen Receptor T Cells With CRISPR Genome EditingSemantic proximity Read ↗

Unleashing the Therapeutic Potential of CAR-T Cell Therapy Using Gene-Editing Technologies.Semantic proximity Read ↗

Ribonucleoprotein Transfection for CRISPR/Cas9‐Mediated Gene Knockout in Primary T CellsSemantic proximity Read ↗

Repurposing base editors for targeted knock-in and simultaneous knockouts to generate multiplex-edited allogeneic CAR T cells with minimal translocationsSemantic proximity Read ↗

Progress and pitfalls of gene editing technology in CAR-T cell therapy: a state-of-the-art reviewSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.