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Diminished expression of major histocompatibility complex facilitates the use of human induced pluripotent stem cells in monkey

3 Aug 2020

Abstract excerpt

BACKGROUND: Stem cells, including induced pluripotent stem cells (iPSCs), have tremendous potential in health care, though with several significant limitations. Each of the limitations, including immunogenicity, may block most of the therapeutic potentials. Beta2 microglobulin (B2M) and MHC II transactivator (CIITA) are critical for MHC I and II, respectively. MHCs are responsible for immunogenic recognition....

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PMID: 32746912
DOI: 10.1186/s13287-020-01847-9

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