Article

Splice switching small molecules as inducers of apoptosis

2018-01-01

Abstract excerpt

One of the most important post-transcriptional processes that occurs during the transcription of DNA to RNA is alternative splicing. Alternative splicing is a highly regulated process that occurs during gene expression and is the basis for the large protein diversity that is achieved in eukaryotes. It allows multiple protein isoforms to be formed from one pre-mRNA sequence. Although alternative splicing is necessa...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 60790dc8-11e1-5b1e-b8b4-26e4edd72861
DOI: 10.48730/f5g4-f135

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Splice switching small molecules as inducers of apoptosisDOI 10.48730/f5g4-f135Read

Specific G-quadruplex ligands modulate the alternative splicing of Bcl-X.Semantic proximity Read

Therapeutic Potential of Splice-Switching OligonucleotidesSemantic proximity Read

Regulating Divergent Transcriptomes through mRNA Splicing and Its Modulation Using Various Small Compounds.Semantic proximity Read

Substances that can change alternative splice-site selectionSemantic proximity Read

Molecular mechanisms by which splice modulator GEX1A inhibits leukaemia development and progression.Semantic proximity Read

Development of site-specific RNA labeling strategies to probe alternative RNA splicingSemantic proximity Read

Alternative splicing of BCL‑X and implications for treating hematological malignancies (Review)Semantic proximity Read

Targeting the spliceosome in chronic lymphocytic leukemia with the macrolides FD-895 and pladienolide-B.Semantic proximity Read

Identification of BAY61-3606 Derivatives With Improved Activity in Splicing Modulation That Induces Inclusion of Cassette Exons Similar to the Splicing Factor 3B Subunit 1 Mutation.Semantic proximity Read

Apogossypol derivatives as antagonists of antiapoptotic Bcl-2 family proteinsSemantic proximity Read

Modulation of 5' splice site selection using tailed oligonucleotides carrying splicing signals.Semantic proximity Read

Protein Splicing Triggered by a Small MoleculeSemantic proximity Read