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Article

Substances that can change alternative splice-site selection

21 May 2008

Abstract excerpt

Alternative pre-mRNA splicing is an important element in eukaryotic gene expression, as most of the protein-coding genes use this process to generate multiple protein isoforms from a single gene. An increasing number of human diseases are now recognized to be caused by the selection of 'wrong' alternative exons. Research during the last few years identified a number of low-molecular-mass chemical substances that...

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PMID: 18481986
DOI: 10.1042/bst0360483

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