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Article

Targeting the spliceosome in chronic lymphocytic leukemia with the macrolides FD-895 and pladienolide-B.

Haematologica - 1 Jul 2015

Kashyap Manoj K, Kumar Deepak, Villa Reymundo, La Clair James J, Benner Chris, Sasik Roman, Jones Harrison, Ghia Emanuela M, Rassenti Laura Z, Kipps Thomas J, Burkart Michael D, Castro Januario E

Abstract excerpt

RNA splicing plays a fundamental role in human biology. Its relevance in cancer is rapidly emerging as demonstrated by spliceosome mutations that determine the prognosis of patients with hematologic malignancies. We report studies using FD-895 and pladienolide-B in primary leukemia cells derived from patients with chronic lymphocytic leukemia and leukemia-lymphoma cell lines. We found that FD-895 and...

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Share to Leukemia, Lymphocytic, Chronic, B-Cell

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Ribonucleoprotein, U2 Small Nuclear

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Source

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Identifiers

PMID: 25862704
DOI: 10.3324/haematol.2014.122069
PMCID: PMC4486229

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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