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Article

Alternative splicing of BCL‑X and implications for treating hematological malignancies (Review)

18 Jul 2021

Abstract excerpt

BCL‑X is a member of the BCL‑2 family. It regulates apoptosis and plays a critical role in hematological malignancies. It is well‑known that >90% of human genes undergo alternative splicing. A total of 10 distinct splicing transcripts of the BCL‑X gene have been identified, including transcript variants 1‑9 and ABALON. Different transcripts from the same gene have different functions. The present review discusses...

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PMID: 34345295
DOI: 10.3892/ol.2021.12931

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