Article
Specific G-quadruplex ligands modulate the alternative splicing of Bcl-X.
Nucleic acids research - 25 Jan 2018
Weldon Carika, Dacanay Justine G, Gokhale Vijay, Boddupally Peda Venkat L, Behm-Ansmant Isabelle, Burley Glenn A, Branlant Christiane, Hurley Laurence H, Dominguez Cyril, Eperon Ian C
Abstract excerpt
Sequences with the potential to form RNA G-quadruplexes (G4s) are common in mammalian introns, especially in the proximity of the 5' splice site (5'SS). However, the difficulty of demonstrating that G4s form in pre-mRNA in functional conditions has meant that little is known about their effects or mechanisms of action. We have shown previously that two G4s form in Bcl-X pre-mRNA, one close to each of the two...
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