Article
Modulation of 5' splice site selection using tailed oligonucleotides carrying splicing signals.
BMC biotechnology - 13 Jan 2006
Gendron Daniel, Carriero Sandra, Garneau Daniel, Villemaire Jonathan, Klinck Roscoe, Elela Sherif Abou, Damha Masad J, Chabot Benoit
Abstract excerpt
BACKGROUND: We previously described the use of tailed oligonucleotides as a means of reprogramming alternative pre-mRNA splicing in vitro and in vivo. The tailed oligonucleotides that were used interfere with splicing because they contain a portion complementary to sequences immediately upstream of the target 5' splice site combined with a non-hybridizing 5' tail carrying binding sites for the hnRNP A1/A2...
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