Article
Molecular mechanisms by which splice modulator GEX1A inhibits leukaemia development and progression.
British journal of cancer - 1 Jul 2022
Sellin Mark, Mack Ryan, Rhodes Matthew C, Zhang Lei, Berg Stephanie, Joshi Kanak, Liu Shanhui, Wei Wei, S J Peter Breslin, Larsen Peter, Taylor Richard E, Zhang Jiwang
Abstract excerpt
INTRODUCTION: Splice modulators have been assessed clinically in treating haematologic malignancies exhibiting splice factor mutations and acute myeloid leukaemia. However, the mechanisms by which such modulators repress leukaemia remain to be elucidated. OBJECTIVES: The primary goal of this assessment was to assess the molecular mechanism by which the natural splice modulator GEX1A kills leukaemic cells in vitro...
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