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Article

The impact of miRNA-based molecular diagnostics and treatment of NRF2-stabilized tumors.

Molecular cancer research : MCR - 1 Jan 2014

Yamamoto Shinsuke, Inoue Jun, Kawano Tatsuyuki, Kozaki Ken-ichi, Omura Ken, Inazawa Johji

Abstract excerpt

UNLABELLED: NF-E2-related factor 2 (NRF2) is a master transcriptional regulator that integrates cellular stress responses and is negatively regulated by Kelch-like ECH-associated protein 1 (KEAP1) at the posttranslational level. In human cancers, aberrantly stabilized NRF2, either by mutation of...

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Source

Identifiers

PMID: 24307696
DOI: 10.1158/1541-7786.MCR-13-0246-T

Genes

KEAP1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-24307696-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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