FOXO1 enhances CAR T cell stemness, metabolic fitness and efficacy.

doi:10.1038/s41586-024-07242-1

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Article

FOXO1 enhances CAR T cell stemness, metabolic fitness and efficacy.

Nature - 1 May 2024

Chan Jack D, Scheffler Christina M, Munoz Isabelle, Sek Kevin, Lee Joel N, Huang Yu-Kuan, Yap Kah Min, Saw Nicole Y L, Li Jasmine, Chen Amanda X Y, Chan Cheok Weng, Derrick Emily B, Todd Kirsten L, Tong Junming, Dunbar Phoebe A, Li Jiawen, Hoang Thang X, de Menezes Maria N, Petley Emma V, Kim Joelle S, Nguyen Dat, Leung Patrick S K, So Joan, Deguit Christian, Zhu Joe, House Imran G, Kats Lev M, Scott Andrew M, Solomon Benjamin J, Harrison Simon J, Oliaro Jane, Parish Ian A, Quinn Kylie M, Neeson Paul J, Slaney Clare Y, Lai Junyun, Beavis Paul A, Darcy Phillip K

Abstract excerpt

Chimeric antigen receptor (CAR) T cell therapy has transformed the treatment of haematological malignancies such as acute lymphoblastic leukaemia, B cell lymphoma and multiple myeloma1-4, but the efficacy of CAR T cell therapy in solid tumours has been limited5. This is owing to a number of factors, including the immunosuppressive tumour microenvironment that gives rise to poorly persisting and metabolically...

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Identifiers

PMID: 38600376
DOI: 10.1038/s41586-024-07242-1
PMCID: PMC11062918

Genes

FOXO1
CD19

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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