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High-Resolution Melt Curve Analysis: An Approach for Mutation Detection in the TPO Gene of Congenital Hypothyroid Patients in Bangladesh

2023-10-18

Abstract excerpt

Thyroid Peroxidase ( TPO ) is known to be the major gene involved in Congenital hypothyroid patients with thyroid dyshormonogenesis. This present study aimed to establish high-resolution melting (HRM) curve analysis as a supplementary mutation detection approach of Sanger sequencing targeting commonly found mutations c.1117G>T, c.1193G>C, and c.2173A>C in the TPO gene in Bangladeshi patients. We enrolled 36 confir...

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Literature Corpus work: 6060d78a-f808-5c3b-bc7e-1daa38407cde
DOI: 10.1101/2023.10.17.23297147

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