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Article

High-resolution melt curve analysis: An approach for variant detection in the TPO gene of congenital hypothyroid patients in Bangladesh.

PloS one - 1 Jan 2024

Begum Mst Noorjahan, Mahtarin Rumana, Islam Md Tarikul, Antora Nusrat Jahan, Sarker Suprovath Kumar, Sultana Nusrat, Sajib Abu A, Islam Abul B M M K, Banu Hurjahan, Hasanat M A, Shyamaly Kohinoor Jahan, Begum Suraiya, Konika Tasnia Kawsar, Haque Shahinur, Hasan Mizanul, Sultana Sadia, Bhuiyan Taufiqur Rahman, Mannoor Kaiissar, Qadri Firdausi, Akhteruzzaman Sharif

Abstract excerpt

TPO (Thyroid Peroxidase) is known to be one of the major genes involved in congenital hypothyroid patients with thyroid dyshormonogenesis. The present study aims to validate high-resolution melting (HRM) curve analysis as a substitute method for Sanger sequencing, focusing on the frequently observed non-synonymous mutations c.1117G>T, c.1193G>C, and c.2173A>C in the TPO gene in patients from Bangladesh. We...

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Identifiers

PMID: 38598477
DOI: 10.1371/journal.pone.0293570
PMCID: PMC11006132

Genes

TPO

Variants

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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