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Thyroid Peroxidase Gene Mutations Associated with Thyroid Disorders.

Biochemistry. Biokhimiia - 1 Jan 2026

Zubkov Alexander V, Butova Ludmila G

Abstract excerpt

The TPO gene belongs to the group of genes responsible for the biosynthesis of thyroid hormones and encodes thyroid peroxidase, a key enzyme involved in this process. Mutations in these genes can result in thyroid dysfunction characterized by reduced levels of thyroid hormones. Hypothyroidism caused by TPO pathogenic variants typically presents as permanent hypothyroidism and is frequently associated with endemic...

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Identifiers

PMID: 41843886
DOI: 10.1134/S0006297925604265

Genes

TPO

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 23 Oct 2026.

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Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

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