Article
High resolution melting curve analysis targeting the HBB gene mutational hot-spot offers a reliable screening approach for all common as well as most of the rare beta-globin gene mutations in Bangladesh.
BMC genetics - 2 Jan 2018
Islam Md Tarikul, Sarkar Suprovath Kumar, Sultana Nusrat, Begum Mst Noorjahan, Bhuyan Golam Sarower, Talukder Shezote, Muraduzzaman A K M, Alauddin Md, Islam Mohammad Sazzadul, Biswas Pritha Promita, Biswas Aparna, Qadri Syeda Kashfi, Shirin Tahmina, Banu Bilquis, Sadya Salma, Hussain Manzoor, Sarwardi Golam, Khan Waqar Ahmed, Mannan Mohammad Abdul, Shekhar Hossain Uddin, Chowdhury Emran Kabir, Sajib Abu Ashfaqur, Akhteruzzaman Sharif, Qadri Syed Saleheen, Qadri Firdausi, Mannoor Kaiissar
Abstract excerpt
BACKGROUND: Bangladesh lies in the global thalassemia belt, which has a defined mutational hot-spot in the beta-globin gene. The high carrier frequencies of beta-thalassemia trait and hemoglobin E-trait in Bangladesh necessitate a reliable DNA-based carrier screening approach that could supplement the use of hematological and electrophoretic indices to overcome the barriers of carrier screening. With this view in...
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