Article
Molecular investigation of TSHR gene in Bangladeshi congenital hypothyroid patients.
PloS one - 1 Jan 2023
Begum Mst Noorjahan, Mahtarin Rumana, Islam Md Tarikul, Ahmed Sinthyia, Konika Tasnia Kawsar, Mannoor Kaiissar, Akhteruzzaman Sharif, Qadri Firdausi
Abstract excerpt
The disorder of thyroid gland development or thyroid dysgenesis accounts for 80-85% of congenital hypothyroidism (CH) cases. Mutations in the TSHR gene are mostly associated with thyroid dysgenesis, and prevent or disrupt normal development of the gland. There is limited data available on the genetic spectrum of congenital hypothyroid children in Bangladesh. Thus, an understanding of the molecular aetiology of...
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